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  • 产品名称：anti-TSC1antibody(TuberousSclerosis1)(pSer312)

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简单介绍：
anti-TSC1antibody(TuberousSclerosis1)(pSer312)
详情介绍：
Immunogen This rat TSC1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S312 of rat TSC1.
Clone RB41267
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name TSC1 (TSC1 Antibody Abstract)
Background In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity).

Synonyms: Tsc1, Hamartin, Tuberous sclerosis 1 protein homolog
NCBI Accession NP_068626
UniProt Q9Z136
Pathways RTK Signaling, AMPK Signaling, Regulation of Cell Size, Tube Formation
Application Notes DB: 1:500
Restrictions For Research Use only
Format Liquid
Concentration 0.32 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Dot Blot (DB) image for anti-Tuberous Sclerosis 1 (TSC1) (pSer312) antibody (ABIN1881907) Dot blot analysis of rat TSC1 Antibody (Phospho S312) Phospho-specific Pab (ABIN18819...
Product cited in: Inoue, Ndong, Suzuki, Kazami, Uyama, Kobayashi, Tadokoro, Yamamoto: "Hamartin-Hsp70 interaction is necessary for Akt-dependent tuberin phosphorylation during heat shock." in: Bioscience, biotechnology, and biochemistry, Vol. 73, Issue 11, pp. 2488-93, 2009 (PubMed).

Di Nardo, Kramvis, Cho, Sadowski, Meikle, Kwiatkowski, Sahin: "Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 18, pp. 5926-37, 2009 (PubMed).

Chen, Yan, Chen, He: "The variation of AkT/TSC1-TSC1/mTOR signal pathway in hepatocytes after partial hepatectomy in rats." in: Experimental and molecular pathology, Vol. 86, Issue 2, pp. 101-7, 2009 (PubMed).

Momose, Kobayashi, Tada, Itoyama, Hino: "N-terminal hamartin-binding and C-terminal GAP domain of tuberin can separate in vivo." in: Biochemical and biophysical research communications, Vol. 356, Issue 3, pp. 693-8, 2007 (PubMed).

Background publications Goncharova, Goncharov, Noonan, Krymskaya: "TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase." in: The Journal of cell biology, Vol. 167, Issue 6, pp. 1171-82, 2004 (PubMed).