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  • 产品名称：anti-DYRK1Aantibody(Dual-Specificitytyrosine-(Y)-phosphorylationRegulatedKinase

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简单介绍：
anti-DYRK1Aantibody(Dual-Specificitytyrosine-(Y)-phosphorylationRegulatedKinase1A)(AA718-745)
详情介绍：
Immunogen This Mouse Dyrk1a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 718-745 amino acids from the C-terminal region of mouse Dyrk1a.
Clone RB40563
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name Dyrk1a (DYRK1A Antibody Abstract)
Background Dyrk1a may play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.

Synonyms: Dyrk1a, Dyrk, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, Dual specificity YAK1-related kinase, MP86, Protein kinase minibrain homolog
NCBI Accession NP_031916, NP_001106860
UniProt Q61214
Pathways Mitotic G1-G1/S Phases
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) (AA 718-745), (C-Term) antibody (ABIN1881275) Mouse Dyrk1a Antibody (C-term) (ABIN1881275) western blot analysis in NCI-H460 cell l...
Product cited in: Park, Oh, Yoo, Jung, Song, Lee, Seo, Chung: "Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells." in: The Journal of biological chemistry, Vol. 285, Issue 41, pp. 31895-906, 2010 (PubMed).

Kurabayashi, Hirota, Sakai, Sanada, Fukada: "DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping." in: Molecular and cellular biology, Vol. 30, Issue 7, pp. 1757-68, 2010 (PubMed).

Guo, Williams, Schug, Li: "DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1." in: The Journal of biological chemistry, Vol. 285, Issue 17, pp. 13223-32, 2010 (PubMed).

Lee, Ha, Kim, Kim, Chang, Song, Kim: "Negative feedback Inhibition of NFATc1 by DYRK1A regulates bone homeostasis." in: The Journal of biological chemistry, Vol. 284, Issue 48, pp. 33343-51, 2009 (PubMed).