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  • 产品名称：anti-XPCantibody(XerodermaPigmentosum,ComplementationGroupC)(AA154-183)

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简单介绍：
anti-XPCantibody(XerodermaPigmentosum,ComplementationGroupC)(AA154-183)
详情介绍：
Immunogen This XPC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 154-183 amino acids from the N-terminal region of human XPC.
Clone RB40964
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name XPC (XPC Antibody Abstract)
Background This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.

Synonyms: XPC, XPCC, DNA repair protein complementing XP-C cells, Xeroderma pigmentosum group C-complementing protein, p125
NCBI Accession NP_001139241, NP_004619
UniProt Q01831
Pathways p53 Signaling, DNA Damage Repair
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.38 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Xeroderma Pigmentosum, Complementation Group C (XPC) (AA 154-183), (N-Term) antibody (ABIN1882000) XPC Antibody (N-term) (ABIN1882000) western blot analysis in ZR-75-1 cell line lysate...
Product cited in: Stern, Lin, Figueroa, Kelsey, Kiltie, Yuan, Matullo, Fletcher, Benhamou, Taylor, Placidi, Zhang, Steineck, Rothman, Kogevinas, Silverman, Malats, Chanock, Wu, Karagas: "Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer." in: Cancer research, Vol. 69, Issue 17, pp. 6857-64, 2009 (PubMed).