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  • 产品名称：anti-STAMantibody(SignalTransducingAdaptorMolecule(SH3DomainandITAMMotif)1)(AA1

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简单介绍：
anti-STAMantibody(SignalTransducingAdaptorMolecule(SH3DomainandITAMMotif)1)(AA1-30)
详情介绍：
Immunogen This STAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human STAM.
Clone RB4633
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name STAM (STAM Antibody Abstract)
Background Stimulation of cells with cytokines initiates a signal transduction cascade involving cytokine receptors, Janus kinases (JAKs) and signal transducers and activators of transcription (STATs). STAM for 'signal-transducing adaptor molecule, induced after stimulation of cells with cytokine IL2, is a component of signal transduction downstream of JAK3.1 Human STAM cDNA cloned from a T-cell cDNA library encodes a 540-amino acid protein precipitated by anti-phosphotyrosine. Northern blot analysis indicates that STAM is expressed as a 2.9-kb message in a wide variety of tissue and cell types. The STAM sequence contains a Src-homology 3 (SH3) domain and an immunoreceptor tyrosine-based activation motif (ITAM). It has been suggested that STAM acts as an adaptor molecule in signal transduction pathways from cytokine receptors.

Synonyms: STAM, STAM1, Signal transducing adapter molecule 1
NCBI Accession NP_003464
UniProt Q92783
Pathways EGFR Signaling Pathway, EGFR Downregulation
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 1 (STAM) (AA 1-30), (N-Term) antibody (ABIN1882134) The anti-STAM Pab (ABIN1882134) is used in Western blot to detect STAM in mouse cereb...
Western Blotting (WB) image for anti-Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 1 (STAM) (AA 1-30), (N-Term) antibody (ABIN1882134) The anti-STAM Pab (ABIN1882134) is used in Western blot to detect STAM in mouse cereb...
Product cited in: Ortiz, Lee, Smith, Forman, Lee, Liu: "Comparative analyses of differentially induced T-cell receptor-mediated phosphorylation pathways in T lymphoma cells." in: Experimental biology and medicine (Maywood, N.J.), Vol. 235, Issue 12, pp. 1450-63, 2010 (PubMed).