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  • 产品名称：anti-SUB1antibody(SUB1Homolog(S.Cerevisiae))(AA18-47)

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  • 产品厂商：半导体
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简单介绍：
anti-SUB1antibody(SUB1Homolog(S.Cerevisiae))(AA18-47)
详情介绍：
Immunogen This SUB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-47 amino acids from the Central region of human SUB1.
Clone RB40953
Predicted Reactivity Monkey
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name SUB1 (SUB1 Antibody Abstract)
Background General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).

Synonyms: SUB1, PC4, RPO2TC1, Activated RNA polymerase II transcriptional coactivator p15, Positive cofactor 4, SUB1 homolog, p14
NCBI Accession NP_006704
UniProt P53999
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-SUB1 Homolog (S. Cerevisiae) (SUB1) (AA 18-47), (Center) antibody (ABIN1881856) SUB1 Antibody (Center) (ABIN1881856) western blot analysis in K562 cell line lysates ...
Product cited in: Das, Gadad, Kundu: "Human positive coactivator 4 controls heterochromatinization and silencing of neural gene expression by interacting with REST/NRSF and CoREST." in: Journal of molecular biology, Vol. 397, Issue 1, pp. 1-12, 2010 (PubMed).

Rajagopalan, Andreeva, Teufel, Freund, Fersht: "Interaction between the transactivation domain of p53 and PC4 exemplifies acidic activation domains as single-stranded DNA mimics." in: The Journal of biological chemistry, Vol. 284, Issue 32, pp. 21728-37, 2009 (PubMed).

Mortusewicz, Roth, Li, Cardoso, Meisterernst, Leonhardt: "Recruitment of RNA polymerase II cofactor PC4 to DNA damage sites." in: The Journal of cell biology, Vol. 183, Issue 5, pp. 769-76, 2008 (PubMed).

Batta, Kundu: "Activation of p53 function by human transcriptional coactivator PC4: role of protein-protein interaction, DNA bending, and posttranslational modifications." in: Molecular and cellular biology, Vol. 27, Issue 21, pp. 7603-14, 2007 (PubMed).

Background publications Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).