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  • 产品名称：anti-CDKN1Aantibody(Cyclin-DependentKinaseInhibitor1A(p21,Cip1))(pSer146)

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简单介绍：
anti-CDKN1Aantibody(Cyclin-DependentKinaseInhibitor1A(p21,Cip1))(pSer146)
详情介绍：
Immunogen This P21CIP1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S146 of human P21CIP1.
Clone RB7515
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name P21CIP1 (CDKN1A Antibody Abstract)
Background This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported.

Synonyms: CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1, Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein 6, p21
NCBI Accession NP_510867, NP_001207707, NP_000380, NP_001207706
UniProt P38936
Pathways p53 Signaling, PI3K-Akt Signaling, Cell Division Cycle, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Hepatitis C, Synthesis of DNA, Autophagy
Application Notes DB: 1:500,WB: 1:1000,IHC (p): 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Dot Blot (DB) image for anti-Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (pSer146) antibody (ABIN1882179) The anti-Phospho- P21CIP1-S146 Pab (ABIN1882179) is used in Western blot to detect Ph...
Western Blotting (WB) image for anti-Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (pSer146) antibody (ABIN1882179) The anti-Phospho- P21CIP1-S146 Pab (ABIN1882179) is used in Western blot to detect Ph...
Product cited in: Suzuki, Yabuta, Okada, Torigata, Aylon, Oren, Nojima: "Lats2 phosphorylates p21/CDKN1A after UV irradiation and regulates apoptosis." in: Journal of cell science, Vol. 126, Issue Pt 19, pp. 4358-68, 2013 (PubMed).

Cornils, Kohler, Hergovich, Hemmings: "Human NDR kinases control G(1)/S cell cycle transition by directly regulating p21 stability." in: Molecular and cellular biology, Vol. 31, Issue 7, pp. 1382-95, 2011 (PubMed).

Scott, Kimura, Dong, Ichinohasama, Bergen, Kerviche, Sheridan, DeCoteau: "Methylation status of cyclin-dependent kinase inhibitor genes within the transforming growth factor beta pathway in human T-cell lymphoblastic lymphoma/leukemia." in: Leukemia research, Vol. 28, Issue 12, pp. 1293-301, 2004 (PubMed).

Amini, Saunders, Kelley, Khalili, Sawaya: "Interplay between HIV-1 Vpr and Sp1 modulates p21(WAF1) gene expression in human astrocytes." in: The Journal of biological chemistry, Vol. 279, Issue 44, pp. 46046-56, 2004 (PubMed).

Chen, Turner, McCarthy, Scaltriti, Bettuzzi, Yeatman: "Clusterin-mediated apoptosis is regulated by adenomatous polyposis coli and is p21 dependent but p53 independent." in: Cancer research, Vol. 64, Issue 20, pp. 7412-9, 2004 (PubMed).

Sieburg, Tripp, Ma, Feuer: "Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 tax oncoproteins modulate cell cycle progression and apoptosis." in: Journal of virology, Vol. 78, Issue 19, pp. 10399-409, 2004 (PubMed).

Giraud, Hurlstone, Avril, Coqueret: "Implication of BRG1 and cdk9 in the STAT3-mediated activation of the p21waf1 gene." in: Oncogene, Vol. 23, Issue 44, pp. 7391-8, 2004 (PubMed).