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  • 产品名称：anti-FOXA1antibody(ForkheadBoxA1)(AA270-298)

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简单介绍：
anti-FOXA1antibody(ForkheadBoxA1)(AA270-298)
详情介绍：
Immunogen This FOXA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 270-298 AA from the Central region of human FOXA1.
Clone RB19432
Isotype Ig
Specificity This FOXA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 270-299 amino acids from the Central region of human FOXA1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name FOXA1 (FOXA1 Antibody Abstract)
Background This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.
Synonyms: Hepatocyte nuclear factor 3-alpha,FOXA1,HNF3A, TCF3A
Research Area Translation Factors, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Signaling, Chromatin, Cell Structure
Pathways Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Carbohydrate Homeostasis
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Western Blotting (WB) image for anti-Forkhead Box A1 (FOXA1) (AA 270-298), (Center), (Ser286) antibody (ABIN658712) FOXA1 Antibody (Center S286) (ABIN658712) western blot analysis in 293 cell line lysa...
Background publications Hu, Gardner-Stephen, Severi, Gregory, Treloar, Giles, English, Hopper, Tilley, Mackenzie: "A novel polymorphism in a forkhead box A1 (FOXA1) of the human UDP glucuronosyltransferase 2B17 gene modulates promoter activity and is associated with altered levels of circulating androstane-3α,17β-diol glucuronide." in: Molecular pharmacology, Vol. 78, Issue 4, pp. 714-22, 2010 (PubMed).

Zhang, Liang, Li, Xuan, Wang, Wang, Shi, Zhang, Shang: "CCCTC-binding factor acts upstream of FOXA1 and demarcates the genomic response to estrogen." in: The Journal of biological chemistry, Vol. 285, Issue 37, pp. 28604-13, 2010 (PubMed).

Liu, Niu, Wang, Yu, Zhang, Liu: "[Diagnostic and prognostic significance of FOXA1 expression in molecular subtypes of breast invasive ductal carcinomas]." in: Zhonghua yi xue za zhi, Vol. 90, Issue 20, pp. 1403-7, 2010 (PubMed).