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  • 产品名称：anti-SMC1Aantibody(StructuralMaintenanceofChromosomes1A)(AA307-336)

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简单介绍：
anti-SMC1Aantibody(StructuralMaintenanceofChromosomes1A)(AA307-336)
详情介绍：
Immunogen This SMC1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-336 AA from the N-terminal region of human SMC1A.
Clone RB33672
Isotype Ig
Specificity This SMC1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 306-336 amino acids from the N-terminal region of human SMC1A.
Predicted Reactivity Cow (Bovine),Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name SMC1A (SMC1A Antibody Abstract)
Background Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. [provided by RefSeq].
Synonyms: Structural maintenance of chromosomes protein 1A,SMC1A,DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1
Molecular Weight 143233 DA
Gene ID 8243
NCBI Accession NP_006297
UniProt Q14683
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Cell Cycle, Chromatin, Neurology, Cell Structure
Pathways Stem Cell Maintenance
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.43 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment SMC1A Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Structural Maintenance of Chromosomes 1A (SMC1A) (AA 307-336), (N-Term) antibody (ABIN657467) SMC1A Antibody (N-term) (ABIN657467) western blot analysis in CEM cell line lysates (...