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  • 产品名称：anti-PCSK6antibody(ProproteinConvertaseSubtilisin/kexinType6)(AA659-688)

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简单介绍：
anti-PCSK6antibody(ProproteinConvertaseSubtilisin/kexinType6)(AA659-688)
详情介绍：
Immunogen This PCSK6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 659-688 AA from the C-terminal region of human PCSK6.
Clone RB34608
Isotype Ig
Specificity This PCSK6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 658-688 amino acids from the C-terminal region of human PCSK6.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name PCSK6 (PCSK6 Antibody Abstract)
Background The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Some of its substrates are - transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms: Proprotein convertase subtilisin/kexin type 6,PCSK6,PACE4
Research Area Cell Signaling, Protein Modifications, Cell Structure, Metabolism
Pathways Neurotrophin Signaling Pathway
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Western Blotting (WB) image for anti-Proprotein Convertase Subtilisin/kexin Type 6 (PCSK6) (AA 659-688), (C-Term) antibody (ABIN658753) PCSK6 Antibody (C-term) (ABIN658753) western blot analysis in K562 cell line lysates ...
Background publications Blanchet, Le Good, Mesnard, Oorschot, Baflast, Minchiotti, Klumperman, Constam: "Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation." in: The EMBO journal, Vol. 27, Issue 19, pp. 2580-91, 2008 (PubMed).