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  • 产品名称：anti-HBEGFantibody(Heparin-BindingEGF-LikeGrowthFactor)(AA68-96)

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简单介绍：
anti-HBEGFantibody(Heparin-BindingEGF-LikeGrowthFactor)(AA68-96)
详情介绍：
Immunogen This HBEGF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-96 AA from the Central region of human HBEGF.
Clone RB34551
Isotype Ig
Specificity This HBEGF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-96 amino acids from the Central region of human HBEGF.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name HBEGF (HBEGF Antibody Abstract)
Background HBEGF may be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
Synonyms: Proheparin-binding EGF-like growth factor,HBEGF,DTR, DTS, HEGFL
Research Area Cell Signaling, Protein Modifications, Cell Structure, Cell Cycle
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Western Blotting (WB) image for anti-Heparin-Binding EGF-Like Growth Factor (HBEGF) (AA 68-96), (Center) antibody (ABIN658749) HBEGF Antibody (Center) (ABIN658749) western blot analysis in K562 cell line lysates ...
Background publications Hamaoka, Chinen, Murata, Takashima, Iwamoto, Mekada: "Anti-human HB-EGF monoclonal antibodies inhibiting ectodomain shedding of HB-EGF and diphtheria toxin binding." in: Journal of biochemistry, Vol. 148, Issue 1, pp. 55-69, 2010 (PubMed).