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  • 产品名称：anti-CDKN1Bantibody(Cyclin-DependentKinaseInhibitor1B(p27,Kip1))(AA147-176)

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简单介绍：
anti-CDKN1Bantibody(Cyclin-DependentKinaseInhibitor1B(p27,Kip1))(AA147-176)
详情介绍：
Immunogen This CDKN1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-176 AA from the C-terminal region of human CDKN1B.
Clone RB33283
Isotype Ig
Specificity This CDKN1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 146-176 amino acids from the C-terminal region of human CDKN1B.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CDKN1B (CDKN1B Antibody Abstract)
Background This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq].
Synonyms: Cyclin-dependent kinase inhibitor 1B,CDKN1B,KIP1
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Protein Modifications, Cancer, Cell Structure
Pathways Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Sensory Perception of Sound, Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA, Autophagy
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.45 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Western Blotting (WB) image for anti-Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) (AA 147-176), (C-Term) antibody (ABIN657225) CDKN1B Antibody (C-term) (ABIN657225) western blot analysis in human normal Uterus ce...
Background publications Kajihara, Fukushige, Shioda, Tanabe, Fukunaga, Inui: "CaMKII phosphorylates serine 10 of p27 and confers apoptosis resistance to HeLa cells." in: Biochemical and biophysical research communications, Vol. 401, Issue 3, pp. 350-5, 2010 (PubMed).

Kedde, van Kouwenhove, Zwart, Oude Vrielink, Elkon, Agami: "A Pumilio-induced RNA structure switch in p27-3' UTR controls miR-221 and miR-222 accessibility." in: Nature cell biology, Vol. 12, Issue 10, pp. 1014-20, 2010 (PubMed).

Canbay, Eraltan, Cercel, Isbir, Gazioglu, Aydogan, Cacina, Cengiz, Ferahman, Zengin, Unal: "CCND1 and CDKN1B polymorphisms and risk of breast cancer." in: Anticancer research, Vol. 30, Issue 7, pp. 3093-8, 2010 (PubMed).