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  • 产品名称：anti-CyclinB1antibody(CCNB1)(AA381-411)

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简单介绍：
anti-CyclinB1antibody(CCNB1)(AA381-411)
详情介绍：
Immunogen This CCNB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 381-411 AA from the C-terminal region of human CCNB1.
Clone RB14992
Isotype Ig
Specificity This CCNB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 388-418 amino acids from the C-terminal region of human CCNB1.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name CCNB1 (CCNB1 Antibody Abstract)
Background The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq].
Synonyms: G2/mitotic-specific cyclin-B1,CCNB1,CCNB
Research Area Ubiquitin-related antibodies, Signaling, Phospho-specific antibodies, Protein Modifications, Cell Cycle, Cell Structure
Pathways Cell Division Cycle, AMPK Signaling, Mitotic G1-G1/S Phases, M Phase
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Immunohistochemistry (IHC) image for anti-Cyclin B1 (CCNB1) (AA 381-411), (C-Term) antibody (ABIN655054) CCNB1 Antibody (C-term) (ABIN655054) immunohistochemistry analysis in formalin fixed ...
Background publications Kreis, Sanhaji, Kr?mer, Sommer, R?del, Strebhardt, Yuan: "Restoration of the tumor suppressor p53 by downregulating cyclin B1 in human papillomavirus 16/18-infected cancer cells." in: Oncogene, Vol. 29, Issue 41, pp. 5591-603, 2010 (PubMed).

Harley, Allan, Sanderson, Clarke: "Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest." in: The EMBO journal, Vol. 29, Issue 14, pp. 2407-20, 2010 (PubMed).