anti-TYSY(AA265-294),(C-Term)antibody 抗体网

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产品名称：anti-TYSY(AA265-294),(C-Term)antibody
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产品厂商：半导体
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简单介绍：

anti-TYSY(AA265-294),(C-Term)antibody

详情介绍：

Product details
Product details
Immunogen	This TYSY antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-294 amino acids from the C-terminal region of human TYSY.
Clone	RB20041
Purification	This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Target details
Target details
Background	Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Synonyms: TYMS, TS, Thymidylate synthase
NCBI Accession	NP_001062
UniProt	P04818

Application Details
Application Details
Application Notes	WB: 1:2000,IHC: 1:500,IF: 1:50,FACS: 1:50
Restrictions	For Research Use only

Handling
Handling
Format	Liquid
Concentration	0.5 mg/mL
Buffer	Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative	Sodium azide
Precaution of Use	WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Images
Images
Supplier Images	TYSY Antibody (C-term) (ABIN1881964) western blot analysis in Hela,Jurkat and HL-60 c... TYSY Antibody (C-term) (ABIN1881964) western blot analysis in Hela,Jurkat and HL-60 c... TYSY Antibody (C-term) (ABIN1881964) western blot analysis in Hela,Jurkat and HL-60 c... TYSY Antibody (C-term) (ABIN1881964) western blot analysis in Hela,Jurkat and HL-60 c... TYSY Antibody (C-term) (ABIN1881964) western blot analysis in Hela,Jurkat and HL-60 c... TYSY Antibody (C-term) (ABIN1881964) western blot analysis in Hela,Jurkat and HL-60 c... Images for product: anti-TYSY (AA 265-294), (C-Term) antibody TYSY Antibody (C-term) (ABIN1881964) western blot analysis in Hela,Jurkat and HL-60 cell line lysates (35 μg/lane). This demonstrates the TYSY antibody detected the TYSY protein (arrow). TYSY Antibody (C-term) (ABIN1881964) western blot analysis in Hela,Jurkat and HL-60 cell line lysates (35 μg/lane). This demonstrates the TYSY antibody detected the TYSY protein (arrow). TYSY Antibody (C-term) (ABIN1881964) western blot analysis in Hela,Jurkat and HL-60 cell line lysates (35 μg/lane). This demonstrates the TYSY antibody detected the TYSY protein (arrow). TYSY Antibody (C-term) (ABIN1881964) western blot analysis in Hela,Jurkat and HL-60 cell line lysates (35 μg/lane). This demonstrates the TYSY antibody detected the TYSY protein (arrow). TYSY Antibody (C-term) (ABIN1881964) western blot analysis in Hela,Jurkat and HL-60 cell line lysates (35 μg/lane). This demonstrates the TYSY antibody detected the TYSY protein (arrow). TYSY Antibody (C-term) (ABIN1881964) western blot analysis in Hela,Jurkat and HL-60 cell line lysates (35 μg/lane). This demonstrates the TYSY antibody detected the TYSY protein (arrow).

References
References
Product cited in:	Ren, Kim, Koh, Chang, Eom, Yi, Seong, Kim, Bronner, Cho: "Comparative analysis of thymidylate synthase at the protein, mRNA, and DNA levels as prognostic markers in colorectal adenocarcinoma." in: Journal of surgical oncology, Vol. 100, Issue 7, pp. 546-52, 2009 (PubMed). Schiffer, Clifton, Davisson, Santi, Stroud: "Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site." in: Biochemistry, Vol. 34, Issue 50, pp. 16279-87, 1996 (PubMed).