产品详情
所在位置: 首页> 产品目录> 一抗>
查看大图

  • 产品名称：anti-Lin-7HomologB(C.Elegans)(LIN7B)(AA35-62),(N-Term)antibody

  • 产品型号：
  • 产品厂商：半导体
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
anti-Lin-7HomologB(C.Elegans)(LIN7B)(AA35-62),(N-Term)antibody
详情介绍：
Immunogen This LIN7B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-62 amino acids from the N-terminal region of human LIN7B.
Clone RB40557
Predicted Reactivity Cow (Bovine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name LIN7B (LIN7B Antibody Abstract)
Background Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ACCN3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity).

Synonyms: LIN7B, MALS2, VELI2, Protein lin-7 homolog B, Mammalian lin-seven protein 2, Vertebrate lin-7 homolog 2
NCBI Accession NP_071448
UniProt Q9HAP6
Pathways Synaptic Membrane
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Lin-7 Homolog B (C. Elegans) (LIN7B) (AA 35-62), (N-Term) antibody (ABIN1881500) LIN7B Antibody (N-term) (ABIN1881500) western blot analysis in CEM cell line lysates ...
Western Blotting (WB) image for anti-Lin-7 Homolog B (C. Elegans) (LIN7B) (AA 35-62), (N-Term) antibody (ABIN1881500) LIN7B Antibody (N-term) (ABIN1881500) western blot analysis in CEM cell line lysates ...
Product cited in: Zucker, Kama, Kuhn, Thu, Orlando, Dunah, Gokce, Taylor, Lambeck, Friedrich, Lindenberg, Faull, Weiller, Young, Luthi-Carter: "Decreased Lin7b expression in layer 5 pyramidal neurons may contribute to impaired corticostriatal connectivity in huntington disease." in: Journal of neuropathology and experimental neurology, Vol. 69, Issue 9, pp. 880-95, 2010 (PubMed).

Sudo, Ito, Iwamoto, Morishita, Asano, Nagata: "Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons." in: Neuroscience research, Vol. 56, Issue 4, pp. 347-55, 2006 (PubMed).

Li, Benard, Margolskee: "Ggamma13 interacts with PDZ domain-containing proteins." in: The Journal of biological chemistry, Vol. 281, Issue 16, pp. 11066-73, 2006 (PubMed).

Kawai, Fukuda, Mukai, Murata: "MJ0917 in archaeon Methanococcus jannaschii is a novel NADP phosphatase/NAD kinase." in: The Journal of biological chemistry, Vol. 280, Issue 47, pp. 39200-7, 2005 (PubMed).