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  • 产品名称：anti-KRT6Aantibody(Keratin6A)(AA212-240)

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简单介绍：
anti-KRT6Aantibody(Keratin6A)(AA212-240)
详情介绍：
Immunogen This Mouse Krt6a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 212-240 amino acids from the Central region of mouse Krt6a.
Clone RB40714
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name Krt6a (KRT6A Antibody Abstract)
Background Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation related keratins). Keratin 6 is found in hair follicles, neck squamous cell carcinomas, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyperproliferative situations. Epidermal injury results in activation of keratinocytes which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation. There are at least six isoforms of human type II keratin 6 (K6), K6A being the most abundant representing about 77% of all forms found in epithelia.

Synonyms: Krt6a, Ker2, Krt2-6, Krt2-6a, Krt6, Keratin, type II cytoskeletal 6A, Cytokeratin-6A, Keratin-6-alpha, Keratin-6A
NCBI Accession NP_032502
UniProt P50446
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.44 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Keratin 6A (KRT6A) (AA 212-240), (Center) antibody (ABIN1881486) Mouse Krt6a Antibody (Center) (ABIN1881486) western blot analysis in mouse bladder ti...
Product cited in: Sehic, Khuu, Risnes, Osmundsen et al.: "Differential gene expression profiling of the molar tooth germ in peroxisome proliferator-activated receptor-alpha (PPAR-alpha) knockout mouse and in wild-type mouse: molar tooth phenotype of..." in: European journal of oral sciences, Vol. 117, Issue 2, pp. 93-104, 2009 (PubMed).

Chen, Jaeger, Den, Koch, Sundberg, Roop: "Mice expressing a mutant Krt75 (K6hf) allele develop hair and nail defects resembling pachyonychia congenita." in: The Journal of investigative dermatology, Vol. 128, Issue 2, pp. 270-9, 2008 (PubMed).

Cui, Kunisada, Esibizione, Grivennikov, Piao, Nedospasov, Schlessinger: "Lymphotoxin-beta regulates periderm differentiation during embryonic skin development." in: Human molecular genetics, Vol. 16, Issue 21, pp. 2583-90, 2007 (PubMed).

Gu, Coulombe: "Keratin expression provides novel insight into the morphogenesis and function of the companion layer in hair follicles." in: The Journal of investigative dermatology, Vol. 127, Issue 5, pp. 1061-73, 2007 (PubMed).

Kurek, Garinis, van Doorninck, van der Wees, Grosveld: "Transcriptome and phenotypic analysis reveals Gata3-dependent signalling pathways in murine hair follicles." in: Development (Cambridge, England), Vol. 134, Issue 2, pp. 261-72, 2006 (PubMed).