anti-NEK3(AA331-361),(Center)antibody 抗体网

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产品名称：anti-NEK3(AA331-361),(Center)antibody
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产品厂商：半导体
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简单介绍：

anti-NEK3(AA331-361),(Center)antibody

详情介绍：

Product details
Product details
Immunogen	This NEK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 331-361 AA from the Central region of human NEK3.
Clone	RB2961
Isotype	Ig
Specificity	This NEK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 339~368 amino acids from the center region of human NEK3.
Purification	This antibody is purified through a protein A column, followed by peptide affinity purification.

Target details
Target details
Background	In Aspergillus nidulans, lack of the serine/threonine kinase NimA (never in mitosis A) results in cell cycle arrest in G2, while overexpression causes the premature onset of mitotic events. NEK3 is similar in sequence to the Aspergillus nidulans protein and may therefore play a role in mitotic regulation. However, the encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. Synonyms: Serine/threonine-protein kinase Nek3, NimA-related protein kinase 3, HSPK 36
Research Area	Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Cell Structure

Application Details
Application Details
Application Notes	WB = 1:1000
Restrictions	For Research Use only

Handling
Handling
Format	Liquid
Concentration	0.5 mg/mL
Buffer	PBS with 0.09 % (W/V) sodium azide
Preservative	Sodium azide
Precaution of Use	This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Images
Images
Supplier Images	NEK3 Antibody (K346) (ABIN652427) western blot analysis in CEM cell line lysates (35 ... Western blot analysis of NEK3 (arrow) using rabbit polyclonal NEK3 Antibody (K346) (A... Images for product: anti-NEK3 (AA 331-361), (Center) antibody NEK3 Antibody (K346) (ABIN652427) western blot analysis in CEM cell line lysates (35 µg/lane).This demonstrates the NEK3 antibody detected the NEK3 protein (arrow). Western blot analysis of NEK3 (arrow) using rabbit polyclonal NEK3 Antibody (K346) (ABIN652427). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the NEK3 gene.

References
References
Product cited in:	McHale, Tomaszewski, Puthiyaveettil, Livolsi, Clevenger: "Altered expression of prolactin receptor-associated signaling proteins in human breast carcinoma." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 21, Issue 5, pp. 565-71, 2008 (PubMed).
Background publications	Kimura, Okano: "Molecular cloning and characterization of the human NIMA-related protein kinase 3 gene (NEK3)." in: Cytogenetics and cell genetics, Vol. 95, Issue 3-4, pp. 177-82, 2002 (PubMed). Schultz, Fry, Sütterlin, Ried, Nigg: "Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 5, Issue 6, pp. 625-35, 1994 (PubMed). Schultz, Nigg: "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 4, Issue 10, pp. 821-30, 1994 (PubMed).