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  • 产品名称：anti-GProtein-CoupledReceptor77(GPR77)(AA297-325),(C-Term)antibody

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简单介绍：
anti-GProtein-CoupledReceptor77(GPR77)(AA297-325),(C-Term)antibody
详情介绍：
Immunogen This GPR77 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 297-325 amino acids from the C-terminal region of human GPR77.
Clone RB42221
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name GPR77 (GPR77 Antibody Abstract)
Background The anaphylatoxins C3a (see MIM 120700), C4a (see MIM 120810), and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate complement activation, anaphylatoxins may be involved in autoimmunity and sepsis. C5L2 is coexpressed with the C5a receptor, C5AR (C5R1, MIM 113995), on polymorphonuclear neutrophils and may modulate C5AR activity.

Synonyms: GPR77, C5L2, C5a anaphylatoxin chemotactic receptor C5L2, G-protein coupled receptor 77
NCBI Accession NP_001258678, NP_001258679, NP_060955
UniProt Q9P296
Research Area Signaling
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.29 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-G Protein-Coupled Receptor 77 (GPR77) (AA 297-325), (C-Term) antibody (ABIN1881388) GPR77 Antibody (C-term) (ABIN1881388) western blot analysis in A549 cell line lysates...
Background publications Bamberg, Mackay, Lee, Zahra, Jackson, Lim, Whitfeld, Craig, Corsini, Lu, Gerard, Gerard: "The C5a receptor (C5aR) C5L2 is a modulator of C5aR-mediated signal transduction." in: The Journal of biological chemistry, Vol. 285, Issue 10, pp. 7633-44, 2010 (PubMed).

Cui, Lapointe, Gauvreau, Kalant, Cianflone: "Recombinant C3adesArg/acylation stimulating protein (ASP) is highly bioactive: a critical evaluation of C5L2 binding and 3T3-L1 adipocyte activation." in: Molecular immunology, Vol. 46, Issue 16, pp. 3207-17, 2009 (PubMed).

Cui, Simaan, Laporte, Lodge, Cianflone: "C5a- and ASP-mediated C5L2 activation, endocytosis and recycling are lost in S323I-C5L2 mutation." in: Molecular immunology, Vol. 46, Issue 15, pp. 3086-98, 2009 (PubMed).

Scola, Johswich, Morgan, Klos, Monk: "The human complement fragment receptor, C5L2, is a recycling decoy receptor." in: Molecular immunology, Vol. 46, Issue 6, pp. 1149-62, 2009 (PubMed).

Scola, Higginbottom, Partridge, Reid, Woodruff, Taylor, Fairlie, Monk: "The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand binding." in: The Journal of biological chemistry, Vol. 282, Issue 6, pp. 3664-71, 2007 (PubMed).

Gerard, Lu, Liu, Craig, Fujiwara, Okinaga, Gerard: "An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2." in: The Journal of biological chemistry, Vol. 280, Issue 48, pp. 39677-80, 2005 (PubMed).