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  • 产品名称：anti-PDE8Bantibody(phosphodiesterase8B)(AA296-324)

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简单介绍：
anti-PDE8Bantibody(phosphodiesterase8B)(AA296-324)
详情介绍：
Immunogen This PDE8B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-324 amino acids from the Central region of human PDE8B.
Clone RB42219
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name PDE8B (PDE8B Antibody Abstract)
Background The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.

Synonyms: PDE8B, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B, Cell proliferation-inducing gene 22 protein
NCBI Accession NP_001025024, NP_003710, NP_001025023, NP_001025022, NP_001025025
UniProt O95263
Research Area Signaling, Enzymes, Metabolism
Pathways Negative Regulation of Hormone Secretion, cAMP Metabolic Process
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-phosphodiesterase 8B (PDE8B) (AA 296-324), (Center) antibody (ABIN1881646) PDE8B Antibody (Center) (ABIN1881646) western blot analysis in mouse heart tissue lys...
Product cited in: Horvath, Faucz, Finkielstain, Nikita, Rothenbuhler, Almeida, Mericq, Stratakis: "Haplotype analysis of the promoter region of phosphodiesterase type 8B (PDE8B) in correlation with inactivating PDE8B mutation and the serum thyroid-stimulating hormone levels." in: Thyroid : official journal of the American Thyroid Association, Vol. 20, Issue 4, pp. 363-7, 2010 (PubMed).

Shields, Freathy, Knight, Hill, Weedon, Frayling, Hattersley, Vaidya: "Phosphodiesterase 8B gene polymorphism is associated with subclinical hypothyroidism in pregnancy." in: The Journal of clinical endocrinology and metabolism, Vol. 94, Issue 11, pp. 4608-12, 2009 (PubMed).

Bimpaki, Nesterova, Stratakis: "Abnormalities of cAMP signaling are present in adrenocortical lesions associated with ACTH-independent Cushing syndrome despite the absence of mutations in known genes." in: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 161, Issue 1, pp. 153-61, 2009 (PubMed).