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  • 产品名称：anti-PDE6Hantibody(phosphodiesterase6H,CGMP-Specific,Cone,gamma)(AA4-33)

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简单介绍：
anti-PDE6Hantibody(phosphodiesterase6H,CGMP-Specific,Cone,gamma)(AA4-33)
详情介绍：
Immunogen This PDE6H antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-33 amino acids from the Central region of human PDE6H.
Clone RB40887
Predicted Reactivity Cow (Bovine),Human,Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name PDE6H (PDE6H Antibody Abstract)
Background This gene encodes the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma). It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are associated with retinal cone dystrophy type 3A (RCD3A).

Synonyms: PDE6H, Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
NCBI Accession NP_006196
UniProt Q13956
Pathways EGFR Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.36 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-phosphodiesterase 6H, CGMP-Specific, Cone, gamma (PDE6H) (AA 4-33), (Center) antibody (ABIN1881645) PDE6H Antibody (Center) (ABIN1881645) western blot analysis in mouse testis tissue ly...
Product cited in: Piri, Gao, Danciger, Mendoza, Fishman, Farber: "A substitution of G to C in the cone cGMP-phosphodiesterase gamma subunit gene found in a distinctive form of cone dystrophy." in: Ophthalmology, Vol. 112, Issue 1, pp. 159-66, 2005 (PubMed).

Kajimura, Yamazaki, Morikawa, Yamazaki, Mayanagi: "Three-dimensional structure of non-activated cGMP phosphodiesterase 6 and comparison of its image with those of activated forms." in: Journal of structural biology, Vol. 139, Issue 1, pp. 27-38, 2002 (PubMed).

Shimizu-Matsumoto, Itoh, Inazawa, Nishida, Matsumoto, Kinoshita, Matsubara, Okubo: "Isolation and chromosomal localization of the human cone cGMP phosphodiesterase gamma cDNA (PDE6H)." in: Genomics, Vol. 32, Issue 1, pp. 121-4, 1996 (PubMed).

Hanna, Kruskal, Ezekowitz, Bloom, Collier: "Role of macrophage oxidative burst in the action of anthrax lethal toxin." in: Molecular medicine (Cambridge, Mass.), Vol. 1, Issue 1, pp. 7-18, 1996 (PubMed).