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  • 产品名称：anti-Integrinbeta2antibody(ITGB2)

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简单介绍：
anti-Integrinbeta2antibody(ITGB2)
详情介绍：
Immunogen Purified His-tagged ITGB2 protein(Fragment) was used to produced this monoclonal antibody.
Clone 534CT6-2-1
Isotype IgG1
Purification Ascites
Alternative Name ITGB2 (ITGB2 Antibody Abstract)
Background The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene.

Synonyms: ITGB2, CD18, MFI7, Integrin beta-2, Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta, Complement receptor C3 subunit beta, CD_antigen=CD18, Flags: Precursor
NCBI Accession NP_001120963, NP_000202
UniProt P05107
Pathways NF-kappaB Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation
Application Notes WB: 1:500-8000
Restrictions For Research Use only
Format Liquid
Buffer Mouse monoclonal antibody supplied in crude ascites with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Integrin beta 2 (ITGB2) antibody (ABIN1882257) ITGB2 Antibody (ABIN1882257) western blot analysis in HL-60 cell line lysates (35 µg/...
Product cited in: Chen, Xie, Nishida, Li, Walz, Springer: "Requirement of open headpiece conformation for activation of leukocyte integrin alphaXbeta2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 33, pp. 14727-32, 2010 (PubMed).

Pliyev, Arefieva, Menshikov: "Urokinase receptor (uPAR) regulates complement receptor 3 (CR3)-mediated neutrophil phagocytosis." in: Biochemical and biophysical research communications, Vol. 397, Issue 2, pp. 277-82, 2010 (PubMed).

Gjelstrup, Boesen, Kragstrup, Jørgensen, Klein, Thiel, Deleuran, Vorup-Jensen: "Shedding of large functionally active CD11/CD18 Integrin complexes from leukocyte membranes during synovial inflammation distinguishes three types of arthritis through differential epitope exposure." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 7, pp. 4154-68, 2010 (PubMed).

Shimada, Miyagawa, Kawashima, Tanaka, Honda, Honda, Tokunaga: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, 2010 (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).