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  • 产品名称：anti-Calcium-SensingReceptor(CASR)(AA260-287),(Center)antibody

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简单介绍：
anti-Calcium-SensingReceptor(CASR)(AA260-287),(Center)antibody
详情介绍：
Immunogen This CASR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 260-287 amino acids from the Central region of human CASR.
Clone RB41198
Predicted Reactivity Cow (Bovine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Alternative Name CASR (CASR Antibody Abstract)
Background The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq].

Synonyms: CASR, GPRC2A, PCAR1, Extracellular calcium-sensing receptor, Parathyroid cell calcium-sensing receptor
NCBI Accession NP_001171536, NP_000379
UniProt P41180
Pathways Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-Calcium-Sensing Receptor (CASR) (AA 260-287), (Center) antibody (ABIN1881139) CASR Antibody (Center) (ABIN1881139) western blot analysis in mouse kidney tissue lys...
Product cited in: OSeaghdha, Yang, Glazer, Leak, Dehghan, Smith, Kao, Lohman, Hwang, Johnson, Hofman, Uitterlinden, Chen, Brown, Siscovick, Harris, Psaty, Coresh, Gudnason, Witteman, Liu, Kestenbaum, Fox, Köttgen: "Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels." in: Human molecular genetics, Vol. 19, Issue 21, pp. 4296-303, 2010 (PubMed).

Giroux, Elfassihi, Clément, Bussières, Bureau, Cole, Rousseau: "High-density polymorphisms analysis of 23 candidate genes for association with bone mineral density." in: Bone, Vol. 47, Issue 5, pp. 975-81, 2010 (PubMed).