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  • 产品名称：anti-ARL6(AA1-30),(N-Term)antibody

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简单介绍：
anti-ARL6(AA1-30),(N-Term)antibody
详情介绍：
Immunogen This ARL6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human ARL6.
Clone RB4921
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. Purified Rabbit Polyclonal Antibody (Pab)
Background ARL6 belongs to the ARF family of GTP-binding proteins. ARF proteins are important regulators of cellular traffic and are the founding members of an expanding family of homologous proteins and genomic sequences. They depart from other small GTP-binding proteins by a unique structural device that implements front-back communication from the N-terminus to the nucleotide-. Studies of the mouse ortholog of this protein suggest an involvement in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been described.

Synonyms: ARL6, ADP-ribosylation factor-like protein 6, Bardet-Biedl syndrome 3 protein
NCBI Accession NP_001265222, NP_816931, NP_115522
UniProt Q9H0F7
Research Area Signaling
Application Notes WB: 1:1000,IHC (p): 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Immunohistochemistry (IHC) image for anti-ARL6 (AA 1-30), (N-Term) antibody (ABIN1882064) Western blot analysis of hARL6-M1 (ABIN1882064) in HL-60 cell line lysates (35 μg/lan...
Western Blotting (WB) image for anti-ARL6 (AA 1-30), (N-Term) antibody (ABIN1882064) Western blot analysis of hARL6-M1 (ABIN1882064) in HL-60 cell line lysates (35 μg/lan...
Product cited in: Wiens, Tong, Esmail, Oh, Gerdes, Wang, Tempel, Rattner, Katsanis, Park, Leroux: "Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signaling." in: The Journal of biological chemistry, Vol. 285, Issue 21, pp. 16218-30, 2010 (PubMed).

Pasqualato, Renault, Cherfils: "Arf, Arl, Arp and Sar proteins: a family of GTP-binding proteins with a structural device for 'front-back' communication." in: EMBO reports, Vol. 3, Issue 11, pp. 1035-41, 2002 (PubMed).

Ingley, Williams, Walker, Tsai, Colley, Sayer, Tilbrook, Sarna, Beaumont, Klinken: "A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit." in: FEBS letters, Vol. 459, Issue 1, pp. 69-74, 1999 (PubMed).

Jacobs, Schilf, Fliegert, Koling, Weber, Schürmann, Joost: "ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal." in: FEBS letters, Vol. 456, Issue 3, pp. 384-8, 1999 (PubMed).