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  • 产品名称：LIMHomeoboxTranscriptionFactor1,alpha(LMX1A)(N-Term)Peptide

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  • 产品厂商：半导体
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简单介绍：
LIMHomeoboxTranscriptionFactor1,alpha(LMX1A)(N-Term)Peptide
详情介绍：
Blocked Antibody anti-LMX1A antibody (LIM Homeobox Transcription Factor 1, alpha) (N-Term) (ABIN2779793)
Characteristics This is a synthetic peptide designed for use in combination with anti-LMX1A antibody (Catalog #: ARP32673_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Purification Purified
Background Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas. The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear genes that bind to specific sequences within the promoter of the insulin gene and interact with RNA polymerase to activate or repress transcription. LMX1 is a homeodomain protein that binds an A/T-rich sequence in the insulin promoter and stimulates transcription of insulin.Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas. The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear genes that bind to specific sequences within the promoter of the insulin gene (INS, MIM 176730) and interact with RNA polymerase to activate or repress transcription. LMX1 is a homeodomain protein that binds an A/T-rich sequence in the insulin promoter and stimulates transcription of insulin (German et al., 1994 [PubMed 7698771]).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-199 AL160058.8 14249-14447 c 200-2447 AK127724.1 362-2609 2448-3382 AL390730.12 9415-10349 c

Alias Symbols: LMX-1, LMX1, LMX1.1, MGC87616

Protein Interaction Partner: BMPR2,ISL1,LDB1,ISL1,LHX3,LMX1A,TCF3

Protein Size: 382
Molecular Weight 43 kDa
Gene ID 4009
NCBI Accession NM_177398, NP_796372
UniProt Q8TE12
Research Area Stem Cells, Transcription Factors, Neurogenesis
Application Notes Each Investigator should determine their own optimal working dilution for specific applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Concentration 1 mg/mL
Buffer Final peptide concentration is 1 mg/mL in PBS.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.