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  • 产品名称：rLq2

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简单介绍：
rLq2
详情介绍：
Sequence QFTQESCTAS NQCWSICKRL HNTNRGKCMN KKCRCYS.
Specificity Lq2 inhibits Kir1.1 K inward rectifier channels , as well as KCa channels .
Characteristics Source: Leiurus quinquestriatus hebraeus (Yellow scorpion).
Molecular formula: C177H280N60O55S7.
Disulfide bonds between Cys7-Cys28, Cys13-Cys33 and Cys17-Cys35.
Purity > 98 %
Molecular Weight 4353
Application Notes 5-50 nM
Comment

K+ channel toxin -KTx 1.2, Charybdotoxin-2, ChTX-Lq2, ChTx-d, Toxin 18-2, Lqh 18-2
Restrictions For Research Use only
Format Lyophilized
Reconstitution Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Concentration after reconstitution: Dissolving 50g in 1.150 ml will provide a stock solution of 10 M.
Handling Advice Soluble in Water.
Product cited in: Lu, MacKinnon: "Purification, characterization, and synthesis of an inward-rectifier K+ channel inhibitor from scorpion venom." in: Biochemistry, Vol. 36, Issue 23, pp. 6936-40, 1997 (PubMed).

Lucchesi, Ravindran, Young, Moczydlowski: "Analysis of the blocking activity of charybdotoxin homologs and iodinated derivatives against Ca2+-activated K+ channels." in: The Journal of membrane biology, Vol. 109, Issue 3, pp. 269-81, 1989 (PubMed).