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  • 产品名称：rAa1(AaTX1)

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简单介绍：
rAa1(AaTX1)
详情介绍：
Sequence QNETNKKCQG GSCASVCRRV IGVAAGKCIN GRCVCYP.
Specificity Aa1 is blocker of A-type voltage-gated transient K+ channels of cerebellar granular cells1.2.
Characteristics Source: Androctonus australis (Sahara scorpion).
Molecular formula: C156H266N54O49S6.
Disulfide bonds between Cys8-Cys28, Cys13-Cys33, and Cys17-Cys35.
Purity > 98 %
Molecular Weight 3868
Application Notes 100 nM - 1M
Comment

K+ channel toxin -KTx 15.4
Restrictions For Research Use only
Format Lyophilized
Reconstitution Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Concentration after reconstitution: Dissolving 50g in 1.293ml will provide a stock solution of 10 M.
Handling Advice Soluble in Water.
Product cited in: Pisciotta, Coronas, Bloch, Prestipino, Possani: "Fast K(+) currents from cerebellum granular cells are completely blocked by a peptide purified from Androctonus australis Garzoni scorpion venom." in: Biochimica et biophysica acta, Vol. 1468, Issue 1-2, pp. 203-12, 2000 (PubMed).

Pisciotta, Ottolia, Possani, Prestipino: "A novel toxin form the scorpion Androctonus australis blocks Shaker K+ channels expressed in Xenopus oocytes." in: Biochemical and biophysical research communications, Vol. 242, Issue 2, pp. 287-91, 1998 (PubMed).

Pisciotta, Coronas, Possani, Prestipino: "The Androctonus australis garzoni scorpion venom contains toxins that selectively affect voltage-dependent K(+)-channels in cerebellum granular cells." in: European biophysics journal : EBJ, Vol. 27, Issue 1, pp. 69-73, 1998 (PubMed).