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  • 产品名称：rMaurocalcine(Mca)

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简单介绍：
rMaurocalcine(Mca)
详情介绍：
Sequence GDCLPHLKLC KENKDCCSKK CKRRGTNIEK RCR.
Specificity Maurocalcine is an agonist of Ryanodine receptor channel (RyR) types 1, 2 and 3.
Characteristics Source: Scorpio maurus palmatus (Chactoid scorpion).
Molecular formula: C156H270N56O46S6.
Disulfide bonds between Cys3-Cys17, Cys10-Cys21, and Cys16-Cys32 .
Purity > 98 %
Molecular Weight 3864
Application Notes 200-400 nM
Restrictions For Research Use only
Format Lyophilized
Reconstitution Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Concentration after reconstitution: Dissolving 50g in 1.295ml will provide a stock solution of 10 M.
Handling Advice Soluble in Water.
Product cited in: Chen, Estève, Sabatier, Ronjat, De Waard, Allen, Pessah: "Maurocalcine and peptide A stabilize distinct subconductance states of ryanodine receptor type 1, revealing a proportional gating mechanism." in: The Journal of biological chemistry, Vol. 278, Issue 18, pp. 16095-106, 2003 (PubMed).

Fajloun, Kharrat, Chen, Lecomte, Di Luccio, Bichet, El Ayeb, Rochat, Allen, Pessah, De Waard, Sabatier: "Chemical synthesis and characterization of maurocalcine, a scorpion toxin that activates Ca(2+) release channel/ryanodine receptors." in: FEBS letters, Vol. 469, Issue 2-3, pp. 179-85, 2000 (PubMed).

Tripathy, Resch, Xu, Valdivia, Meissner: "Imperatoxin A induces subconductance states in Ca2+ release channels (ryanodine receptors) of cardiac and skeletal muscle." in: The Journal of general physiology, Vol. 111, Issue 5, pp. 679-90, 1998 (PubMed).