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  • 产品名称：rAgitoxin-2(AgTx2)

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简单介绍：
rAgitoxin-2(AgTx2)
详情介绍：
Sequence GVPINVSCTG SPQCIKPCKD AGMRFGKCMN RKCHCTPK.
Specificity Agitoxin-2 is a blocker of Shaker voltage-gated K+ channels as well as the mammalian homologues of Shaker.
Characteristics Source: Leiurus quinquestriatus hebraeus (Yellow scorpion).
Molecular formula: C169H278N54O48S8.
Disulfide bonds between Cys8-Cys28, Cys14-Cys33, and Cys18-Cys35.
Purity > 98 %
Molecular Weight 4091
Application Notes 50 pM - 10 nM
Comment

K+ channel toxin -KTx 3.2
Restrictions For Research Use only
Format Lyophilized
Reconstitution Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Concentration after reconstitution: Dissolving 50g in 1.222ml will provide a stock solution of 10 M.
Handling Advice Soluble in Water.
Product cited in: Cayabyab, Khanna, Jones, Schlichter: "Suppression of the rat microglia Kv1.3 current by src-family tyrosine kinases and oxygen/glucose deprivation." in: The European journal of neuroscience, Vol. 12, Issue 6, pp. 1949-60, 2000 (PubMed).

Garcia, Garcia-Calvo, Hidalgo, Lee, MacKinnon: "Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom." in: Biochemistry, Vol. 33, Issue 22, pp. 6834-9, 1994 (PubMed).