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  • 产品名称：rATXIINeurotoxin2,ToxinATX-II,As2,Anemoniaviridistoxin2,Av2)

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简单介绍：
rATXIINeurotoxin2,ToxinATX-II,As2,Anemoniaviridistoxin2,Av2)
详情介绍：
Sequence GVPCLCDSDG PSVRGNTLSG IIWLAGCPSG WHNCKKHGPT IGWCCKQ.
Specificity ATX II is a potently modulates voltage-gated Na+ channel gating kinetics by delaying its inactivation and prolonging the action potential of excitable membranes. ATX II has been used as a powerful activator of TTX-sensitive and insensitive Na+ channels in various excitable tissue and cell types1-4.
Characteristics Source: Anemonia sulcata, Anemonia viridis (Mediterranean snakelocks sea anemone).
Molecular formula: C213H324N64O60S6.
Disulfide bonds between Cys4-Cys44, Cys6-Cys34, and Cys27-Cys45.
Purity > 98 %
Molecular Weight 4935
Application Notes 10-100 nM
Comment

Neurotoxin 2, Toxin ATX-II, As2, Anemonia viridis toxin 2, Av2
Restrictions For Research Use only
Format Lyophilized
Reconstitution Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Concentration after reconstitution: Dissolving 50g in 1.013ml will provide a stock solution of 10 M.
Handling Advice Soluble in Water.
Product cited in: Brand, Seeger, Alzheimer: "Enhancement of persistent Na+ current by sea anemone toxin (ATX II) exerts dual action on hippocampal excitability." in: The European journal of neuroscience, Vol. 12, Issue 7, pp. 2387-96, 2000 (PubMed).

Tripathy, Resch, Xu, Valdivia, Meissner: "Imperatoxin A induces subconductance states in Ca2+ release channels (ryanodine receptors) of cardiac and skeletal muscle." in: The Journal of general physiology, Vol. 111, Issue 5, pp. 679-90, 1998 (PubMed).

Nishio, Ohmura, Kigoshi, Muramatsu: "Supersensitivity to tetrodotoxin and lignocaine of sea anemone toxin II-treated sodium channel in guinea-pig ventricular muscle." in: British journal of pharmacology, Vol. 104, Issue 2, pp. 504-8, 1992 (PubMed).

Tesseraux, Gülden, Wassermann: "Cultured myotubes from skeletal muscle of ***** rats. Characterization and action of Anemonia sulcata toxin II." in: Naunyn-Schmiedeberg's archives of pharmacology, Vol. 336, Issue 2, pp. 232-9, 1988 (PubMed).

Romey, Abita, Schweitz, Wunderer, Lazdunski: "Sea anemone toxin:a tool to study molecular mechanisms of nerve conduction and excitation-secretion coupling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 73, Issue 11, pp. 4055-9, 1977 (PubMed).