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  • 产品名称：rPsalmotoxin-1

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  • 产品厂商：BioLeaf
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简单介绍：
rPsalmotoxin-1
详情介绍：
Sequence EDCIPKWKGC VNRHGDCCEG LECWKRRRSF EVCVPKTPKT .
Specificity Psalmotoxin-1 inhibits cation currents mediated by acid-sensing ion channels (ASIC1a).
Characteristics Source: Psalmopoeus cambridgei (Trinidad chevron tarantula) 1, 2.
Molecular formula: C200H312N62O57S6.
Disulfide bonds between Cys3-Cys18, Cys10-Cys23, and Cys17-Cys33.
Purity > 98 %
Molecular Weight 4695
Application Notes 1-10 nM
Comment

PcTx-1, -theraphotoxin-Pc1a, -TRTX-Pc1a
Restrictions For Research Use only
Format Lyophilized
Reconstitution Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Concentration after reconstitution: Dissolving 50g in 1.065ml will provide a stock solution of 10 M.
Handling Advice Soluble in Water.
Product cited in: Sluka, Radhakrishnan, Benson, Eshcol, Price, Babinski, Audette, Yeomans, Wilson: "ASIC3 in muscle mediates mechanical, but not heat, hyperalgesia associated with muscle inflammation." in: Pain, Vol. 129, Issue 1-2, pp. 102-12, 2007 (PubMed).

Jasti, Furukawa, Gonzales, Gouaux: "Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH." in: Nature, Vol. 449, Issue 7160, pp. 316-23, 2007 (PubMed).

Mazzuca, Heurteaux, Alloui, Diochot, Baron, Voilley, Blondeau, Escoubas, Gélot, Cupo, Zimmer, Zimmer, Eschalier, Lazdunski: "A tarantula peptide against pain via ASIC1a channels and opioid mechanisms." in: Nature neuroscience, Vol. 10, Issue 8, pp. 943-5, 2007 (PubMed).

Background publications Escoubas, De Weille, Lecoq, Diochot, Waldmann, Champigny, Moinier, Ménez, Lazdunski: "Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels." in: The Journal of biological chemistry, Vol. 275, Issue 33, pp. 25116-21, 2000 (PubMed).