产品详情
所在位置: 首页> 产品目录> 辅助试剂>
  • 产品名称:LysophosphatidicAcidReceptor1(EDG2)

  • 产品型号:
  • 产品厂商:Exalpha
  • 产品文档:
你添加了1件商品 查看购物车
简单介绍:
LysophosphatidicAcidReceptor1(EDG2)
详情介绍:
Alternative Name Lysophosphatidic Acid Receptor 1
Background Endothelial cell differentiation gene-2 (EDG2) receptor is a high affinity receptor for lysophosphatidic acid (LPA). EDG2 (LPA1), also known as lysophospholipid receptor A1, Vzg-1, mrec1.3 or GPCR26, like all other EDG receptors, couple multiple (3 or more) types of G proteins and transduce decreases in c[AMP]i through Gi and increases in [Ca2+]i by augmenting phospholipase C through Gq/11 and beta/gamma dimers and by induction of PI3 kinase, p125 FAK, phospholipase D by activating rho through G12/13. Human EDG-2 is present in high levels on oligodendrocytes and certain human malignant T cell lines. EDG2 (LPA1) receptors (with EDG4) may play a role in protecting cardiomyocytes from apoptosis induced by hypoxia and andrenergic stimulation.
Restrictions For Research Use only
Storage -80 °C