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Background
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Endothelin 2, also known as ET-2, is a protein that in humans is encoded by the EDN2 gene. This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation.
Synonyms: ET2, PPET2
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