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  • 产品名称：Riluzole

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Riluzole
详情介绍：
Purpose Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons. In the presence of negative potentials, Riluzole was shown to also block tetrodotoxin-resistant sodium channels. It has been reported that Riluzole exerts its neuroprotective action under ischemic conditions, thereby suppressing glutamatergic receptor stimulation and calcium influx. Research shows that this product activates the TREK family of potassium channels and directly affects the glutamatergic system. Riluzole inhibits glutamate release from presynaptic terminals and increases Na+-dependent glutamate uptake in rat cortical synaptosomes. Riluzole blocks voltage-dependent Na+ channels and inhibits GABA uptake by striatal synaptosomes.
Characteristics Tradename: RILUZOLE
Source of Compound: synthetic
Target: GluR antagonist, Sodium Channel inhibitor
Receptor: NMDA receptor ,Sodium channel
Status: USP
Purification All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Purity 98 %
Formula C8H5F3N2OS
Solubility Soluble in DMSO > 10 Mm
Molecular Weight 234.20 g/mol
CAS-No 1744-22-5
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Solid
Storage -20 °C
Storage Comment For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Expiry Date 24 months
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image for Riluzole (ABIN4869399) Riluzole