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  • 产品名称：anti-P2RX7antibody(PurinergicReceptorP2X,Ligand-GatedIonChannel,7)(C-Term)

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简单介绍：
anti-P2RX7antibody(PurinergicReceptorP2X,Ligand-GatedIonChannel,7)(C-Term)
详情介绍：
Immunogen Recombinant cytoplasmic C-terminal tail of mouse P2X7 (aa 363-595).
Specificity Specific for P2X7.
Purification Affinity purified with the immunogen. Rabbit serum albumin was added for stabilization.
Alternative Name P2X7 (P2RX7 Antibody Abstract)
Pathways Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Synaptic Vesicle Exocytosis
Application Notes WB: 1 : 1000 (AP staining)
IP: not tested yet
ICC: not tested yet
IHC: not tested yet
Comment

Detects mouse protein with higher sensitivity. This antibody detects an additional band at 30 kDa of unknown identity.
Restrictions For Research Use only
Format Lyophilized
Reconstitution For reconstitution add 50 μL H2O to get a 1mg/ml solution of antibody in PBS. Then aliquot and store at -20 °C until use.
Buffer PBS
Handling Advice Affinity purified antibodies are less robust than antisera, since protease inhibitors are also removed during purification. Hence, storage at 4?°C for prolonged periods (i.e. several weeks), is not recommended.
Storage -20 °C
Storage Comment Unlabeled lyophilized antibodies are stable in this form without loss of quality at ambient temperatures for several weeks or even months. They can be stored at 4°C for several years. Lyophilized antibodies must not be stored in the freezer, they may be destroyed!
Supplier Images
Western Blotting (WB) image for anti-Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) (AA 363-595), (C-Term) antibody (ABIN1742370) dilution: 1 : 1000, sample: mouse spleen extract (wt and P2X7 knock out)
Product cited in: Young, Sinadinos, Lefebvre, Chan, Arkle, Vaudry, Gorecki: "A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90." in: Autophagy, Vol. 11, Issue 1, pp. 113-30, 2015 (PubMed).

Young, Brutkowski, Lien, Arkle, Lochmüller, Zab?ocki, Górecki: "P2X7 purinoceptor alterations in dystrophic mdx mouse muscles: relationship to pathology and potential target for treatment." in: Journal of cellular and molecular medicine, Vol. 16, Issue 5, pp. 1026-37, 2012 (PubMed).

Masin, Young, Lim, Barnes, Xu, Marschall, Brutkowski, Mooney, Gorecki, Murrell-Lagnado: "Expression, assembly and function of novel C-terminal truncated variants of the mouse P2X7 receptor: re-evaluation of P2X7 knockouts." in: British journal of pharmacology, Vol. 165, Issue 4, pp. 978-93, 2012 (PubMed).