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  • 产品名称:anti-Abeta-pE3antibody

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简单介绍:
anti-Abeta-pE3antibody
详情介绍:
Immunogen Synthetic peptide pyr-EFRHD coupled to key-hole limpet hemocyanin via an added C-terminal cysteine residue.
Specificity Specific for Abeta-pE3.
Purification Affinity purified with the immunogen. Rabbit serum albumin was added for stabilization.
Background Synonyms: pyro-Glu Abeta, pE-Abeta, pGlu-Abeta, Abeta(3(pE)-40/42)
Application Notes WB: 1 : 1000
IP: not tested yet
ICC: not tested yet
IHC: 1 : 500
IHC-P: 1 : 200
Comment

WB: Detects purified Abeta pE3. Complex samples like brain extracts still have to be tested.

Restrictions For Research Use only
Format Lyophilized
Reconstitution For reconstitution add 50 μL H2O to get a 1mg/ml solution of antibody in PBS. Then aliquot and store at -20 °C until use.
Buffer PBS
Handling Advice Affinity purified antibodies are less robust than antisera, since protease inhibitors are also removed during purification. Hence, storage at 4?°C for prolonged periods (i.e. several weeks), is not recommended.
Storage -20 °C
Storage Comment Unlabeled lyophilized antibodies are stable in this form without loss of quality at ambient temperatures for several weeks or even months. They can be stored at 4°C for several years. Lyophilized antibodies must not be stored in the freezer, they may be destroyed!
Supplier Images
Western Blotting (WB) image for anti-Abeta-pE3 antibody (ABIN1742435) Detection of different synthetic Abeta species (dilution 1 : 1000). Peptides have bee...
Immunohistochemistry (IHC) image for anti-Abeta-pE3 antibody (ABIN1742435) Immunostaining of a PFA fixed brain section from a 5XFAD mouse (dilution 1 : 500).
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Abeta-pE3 antibody (ABIN1742435) Immunostaining of paraffin embedded sections from an Alzheimer's patient (dilution 1 ...
Product cited in: Morawski, Schilling, Kreuzberger, Waniek, J?ger, Koch, Cynis, Kehlen, Arendt, Hartlage-Rübsamen, Demuth, Ro?ner: "Glutaminyl cyclase in human cortex: correlation with (pGlu)-amyloid-? load and cognitive decline in Alzheimer's disease." in: Journal of Alzheimer's disease : JAD, Vol. 39, Issue 2, pp. 385-400, 2014 (PubMed).

Becker, Kohlmann, Alexandru, Jagla, Canneva, B?uscher, Cynis, Sedlmeier, Graubner, Schilling, Demuth, von H?rsten: "Glutaminyl cyclase-mediated toxicity of pyroglutamate-beta amyloid induces striatal neurodegeneration." in: BMC neuroscience, Vol. 14, pp. 108, 2013 (PubMed).

Nussbaum, Schilling, Cynis, Silva, Swanson, Wangsanut, Tayler, Wiltgen, Hatami, R?nicke, Reymann, Hutter-Paier, Alexandru, Jagla, Graubner, Glabe, Demuth, Bloom: "Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β." in: Nature, Vol. 485, Issue 7400, pp. 651-5, 2012 (PubMed).

Morawski, Brückner, J?ger, Seeger, Matthews, Arendt: "Involvement of perineuronal and perisynaptic extracellular matrix in Alzheimer's disease neuropathology." in: Brain pathology (Zurich, Switzerland), Vol. 22, Issue 4, pp. 547-61, 2012 (PubMed).

Hartlage-Rübsamen, Morawski, Waniek, J?ger, Zeitschel, Koch, Cynis, Schilling, Schliebs, Demuth, Rossner: "Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-A? deposits in hippocampus via distinct cellular mechanisms." in: Acta neuropathologica, Vol. 121, Issue 6, pp. 705-19, 2011 (PubMed).

Alexandru, Jagla, Graubner, Becker, B?uscher, Kohlmann, Sedlmeier, Raber, Cynis, R?nicke, Reymann, Petrasch-Parwez, Hartlage-Rübsamen, Waniek, Rossner, Schilling, Osmand, Demuth, von H?rsten: "Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 36, pp. 12790-801, 2011 (PubMed).