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  • 产品名称：anti-SHANK3antibody(SH3andMultipleAnkyrinRepeatDomains3)(AA1055-1616)

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简单介绍：
anti-SHANK3antibody(SH3andMultipleAnkyrinRepeatDomains3)(AA1055-1616)
详情介绍：
Immunogen Recombinant protein (aa 1055-1616 of rat shank 3).
Specificity Specific for shank 3.
Purification antiserum
Alternative Name Shank 3 (SHANK3 Antibody Abstract)
Background Synonyms: ProSAP2, SPANK2
Pathways Synaptic Membrane, Tube Formation, Regulation of long-term Neuronal Synaptic Plasticity
Application Notes WB: 1 : 1000 (AP staining)
IP: not tested yet
ICC: 1 : 500
IHC: 1 : 500
Comment

IHC: For best results the antibody requires a mild fixation protocol (2 % PFA in sodium acetate buffer, pH 6).
Restrictions For Research Use only
Format Liquid
Buffer PBS
Handling Advice Crude antisera are more robust than monoclonals. With anti-microbials added, they may be stored at 4?°C.
Serum does not contain active proteases, in fact, serum itself contains a powerful cocktail of protease inhibitors. Frozen storage (-20?°C),however, is preferable.
Storage 4 °C/-20 °C
Storage Comment Unlabeled antibodies are stable in this form without loss of quality at ambient temperatures for several weeks or even months. They can be stored at 4 °C for several years.
Supplier Images
Western Blotting (WB) image for anti-SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) (AA 1055-1616) antibody (ABIN1742347) dilution: 1 : 1000, sample: rat hippocampus homogenate
Immunocytochemistry (ICC) image for anti-SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) (AA 1055-1616) antibody (ABIN1742347) Indirect immunolabeling of PFA fixed rat hippocampus neurons with anti-shank 3 (dilut...
Immunohistochemistry (IHC) image for anti-SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) (AA 1055-1616) antibody (ABIN1742347) Indirect immunostaining of PFA fixed cerebellum sections (dilution 1 : 500).
Product cited in: Tao-Cheng, Toy, Winters, Reese, Dosemeci: "Zinc Stabilizes Shank3 at the Postsynaptic Density of Hippocampal Synapses." in: PLoS ONE, Vol. 11, Issue 5, pp. e0153979, 2016 (PubMed).

Wei, Ma, Ding, Jin, Liu, Chang, Hu, Yu: "Reduced Glutamate Release in Adult BTBR Mouse Model of Autism Spectrum Disorder." in: Neurochemical research, Vol. 41, Issue 11, pp. 3129-3137, 2016 (PubMed).

Wei, Ma, Liu, Ding, Jin, Wang, Hu, Yu: "Inhibition of IL-6 trans-signaling in the brain increases sociability in the BTBR mouse model of autism." in: Biochimica et biophysica acta, Vol. 1862, Issue 10, pp. 1918-25, 2016 (PubMed).

Hagmeyer, Mangus, Boeckers, Grabrucker: "Effects of trace metal profiles characteristic for autism on synapses in cultured neurons." in: Neural plasticity, Vol. 2015, pp. 985083, 2015 (PubMed).