anti-APPantibody(Amyloidbeta(A4)PrecursorProtein)(C-Term) 抗体网

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产品名称：anti-APPantibody(Amyloidbeta(A4)PrecursorProtein)(C-Term)
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产品厂商：SYSY
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简单介绍：

anti-APPantibody(Amyloidbeta(A4)PrecursorProtein)(C-Term)

详情介绍：

Product Details anti-APP Antibody
Product Details anti-APP Antibody
Immunogen	Synthetic peptide GYENPTYKFFEQMQN corresponding to the C-terminus of APP coupled to key-hole limpet hemocyanin via an added N-terminal cysteine residue.
Specificity	Specific for APP.
Purification	Affinity purified with the immunogen. Rabbit serum albumin was added for stabilization.

Target Details APP
Target Details APP
Alternative Name	APP (APP Antibody Abstract)
Research Area	Signaling
Pathways	Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour

Application Details
Application Details
Application Notes	WB: 1 : 500 up to 1 : 1000 (AP staining) IP: not tested yet ICC: 1 : 500 IHC-P: 1 : 2000
Comment	IHC/IHC-P: The affinity purified antibody is highly recommended.
Restrictions	For Research Use only

Handling
Handling
Format	Lyophilized
Reconstitution	For reconstitution add 50 μL H2O to get a 1mg/ml solution of antibody in PBS. Then aliquot and store at -20 °C until use.
Buffer	PBS
Handling Advice	Affinity purified antibodies are less robust than antisera, since protease inhibitors are also removed during purification. Hence, storage at 4?°C for prolonged periods (i.e. several weeks), is not recommended.
Storage	-20 °C
Storage Comment	Unlabeled lyophilized antibodies are stable in this form without loss of quality at ambient temperatures for several weeks or even months. They can be stored at 4°C for several years. Lyophilized antibodies must not be stored in the freezer, they may be destroyed!

Images
Images
Supplier Images	dilution: 1 : 1000, sample: enriched synaptosomal membranes Indirect immunostaining of PFA fixed mouse hippocampus neurons with anti-APP (dilutio... Immunostaining of paraffin embedded brain section from transgenic mouse expressing hu... Immunostaining of a PFA fixed formic acid treated brain section from an triple transg... Images for product: anti-Amyloid beta (A4) Precursor Protein (APP) (C-Term) antibody dilution: 1 : 1000, sample: enriched synaptosomal membranes Indirect immunostaining of PFA fixed mouse hippocampus neurons with anti-APP (dilution 1 : 500; red) and mouse anti-Synapsin 1 (cat. no. 106 011, dilution 1 : 500; green). Immunostaining of paraffin embedded brain section from transgenic mouse expressing human APP (dilution 1 : 2000). Immunoreactivity in dystrophic dendrites surrounding amyloid plaques was revealed using diaminobenzidine as chromagen. Nuclei were counterstained with haematoxylin (blue). Immunostaining of a PFA fixed formic acid treated brain section from an triple transgenic Alzheimer mouse with anti-APP (dilution 1 : 200; red) and biotinylated mouse anti-Abeta (cat. no: 218 211BT, dilution 1 : 200, green). Nuclei nuclei have been visualized by DAPI staining (blue).

References for anti-APP antibody (ABIN1742281)
References for anti-APP antibody (ABIN1742281)
Product cited in:	Groemer, Thiel, Holt, Riedel, Hua, Hüve, Wilhelm, Klingauf: "Amyloid precursor protein is trafficked and secreted via synaptic vesicles." in: PLoS ONE, Vol. 6, Issue 4, pp. e18754, 2011 (PubMed).