anti-Abeta38/40/42(AA1-16),(AA4-8)antibody 抗体网

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产品名称：anti-Abeta38/40/42(AA1-16),(AA4-8)antibody
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产品厂商：SYSY
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简单介绍：

anti-Abeta38/40/42(AA1-16),(AA4-8)antibody

详情介绍：

Product details
Product details
Immunogen	Synthetic peptide (aa 1-16) of abeta peptides 38, 40, 42 coupled to key-hole limpet hemocyanin via an added C-terminal cysteine residue. Epitope aa 4-8
Clone	NT244
Isotype	IgG2b
Specificity	Specific for Abeta 38, 40, 42.
Purification	purified IgG. Azide was added before lyophilization.

Target details
Target details

Application Details
Application Details
Application Notes	WB: 1 : 500 up to 1 : 1000 IP: not tested yet ICC: not tested yet IHC-P: 1 : 500 ELISA: not tested yet
Restrictions	For Research Use only

Handling
Handling
Format	Lyophilized
Reconstitution	For reconstitution add 100 μL H2O to get a 1mg/ml solution of antibody in PBS. Then aliquot and store at -20 °C until use.
Buffer	PBS, 0.02% sodium azide
Preservative	Sodium azide
Precaution of Use	This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice	Do not store diluted antibody solutions unless you add detergent or carrier proteins such as goat serum, BSA or others. IgG sticks to glass and plastic. Any IgG solution below 0.1?mg/mL protein will quickly adsorb and denature and thus loose activity! Repetitive freeze-thawing of dilute purified IgG is almost certain to lead to substantial losses.
Storage	-20 °C
Storage Comment	Unlabeled antibodies are stable in this form without loss of quality at ambient temperatures for several weeks or even months. They can be stored at 4 °C for several years.

Images
Images
Supplier Images	WB detection (ECL) of Abeta peptides (dilution 1 : 500). 0: Synthetic Abeta 1-42. A: ... anti-Abeta 38/40/42 (AA 1-16), (AA 4-8) antibody (Image 2) Immunostaining of paraffin embedded brain section from an Alzheimer′s patient (diluti... Images for product: anti-Abeta 38/40/42 (AA 1-16), (AA 4-8) antibody WB detection (ECL) of Abeta peptides (dilution 1 : 500). 0: Synthetic Abeta 1-42. A: Brain extract from WT mouse. B: Brain extract from heterozygous mouse overexpressing APP. C: brain extract from homozygous mouse overexpressing APP. anti-Abeta 38/40/42 (AA 1-16), (AA 4-8) antibody (Image 2) Immunostaining of paraffin embedded brain section from an Alzheimer′s patient (dilution 1 : 500). Immunoreactivity in amyloid plaques was revealed using diaminobenzidine as chromagen. Nuclei were counterstained with haematoxylin (blue).

References
References
Product cited in:	Porcellotti, Fanelli, Fracassi, Sepe, Cecconi, Bernardi, Cimini, Cerù, Moreno: "Oxidative Stress during the Progression of β-Amyloid Pathology in the Neocortex of the Tg2576 Mouse Model of Alzheimer's Disease." in: Oxidative medicine and cellular longevity, Vol. 2015, pp. 967203, 2015 (PubMed). Reinert, Martens, Huettenrauch, Kolbow, Lannfelt, Ingelsson, Paetau, Verkkoniemi-Ahola, Bayer, Wirths: "Aβ38 in the brains of patients with sporadic and familial Alzheimer's disease and transgenic mouse models." in: Journal of Alzheimer's disease : JAD, Vol. 39, Issue 4, pp. 871-81, 2014 (PubMed). Wirths, Hillmann, Pradier, H?rtig, Bayer: "Oligomeric pyroglutamate amyloid-β is present in microglia and a subfraction of vessels in patients with Alzheimer's disease: implications for immunotherapy." in: Journal of Alzheimer's disease : JAD, Vol. 35, Issue 4, pp. 741-9, 2013 (PubMed). Venkataramani, Wirths, Budka, H?rtig, Kovacs, Bayer: "Antibody 9D5 recognizes oligomeric pyroglutamate amyloid-β in a fraction of amyloid-β deposits in Alzheimer's disease without cross-reactivity with other protein aggregates." in: Journal of Alzheimer's disease : JAD, Vol. 29, Issue 2, pp. 361-71, 2012 (PubMed).