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  • 产品名称：anti-Abeta-pE3antibody

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  • 产品厂商：SYSY
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简单介绍：
anti-Abeta-pE3antibody
详情介绍：
Immunogen Synthetic peptide pyr-EFRHD coupled to key-hole limpet hemocyanin via an added C-terminal cysteine residue. Epitope Minimal epitope: pyr-EFR.
Clone 1-57
Isotype IgG2b
Specificity Specific for Abeta-pE3.
Purification purified IgG. Azide was added before lyophilization.
Background Synonyms: pyro-Glu Abeta, pE-Abeta, pGlu-Abeta, Abeta(3(pE)-40/42)
Application Notes WB: 1 : 1000
ICC: not tested yet
IHC: 1 : 100
Comment

WB: Detects purified Abeta pE3. Complex samples like brain extracts still have to be tested.
Restrictions For Research Use only
Format Lyophilized
Reconstitution For reconstitution add 100 μL H2O to get a 1mg/ml solution of antibody in PBS. Then aliquot and store at -20 °C until use.
Buffer PBS, 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do not store diluted antibody solutions unless you add detergent or carrier proteins such as goat serum, BSA or others. IgG sticks to glass and plastic. Any IgG solution below 0.1?mg/mL protein will quickly adsorb and denature and thus loose activity! Repetitive freeze-thawing of dilute purified IgG is almost certain to lead to substantial losses.
Storage -20 °C
Storage Comment Unlabeled antibodies are stable in this form without loss of quality at ambient temperatures for several weeks or even months. They can be stored at 4 °C for several years.
Supplier Images
Western Blotting (WB) image for anti-Abeta-pE3 antibody (ABIN1742433) Detection of different synthetic Abeta species (dilution 1 : 1000). Peptides have bee...
Product cited in: Antonios, Saiepour, Bouter, Richard, Paetau, Verkkoniemi-Ahola, Lannfelt, Ingelsson, Kovacs, Pillot, Wirths, Bayer: "N-truncated Abeta starting with position four: early intraneuronal accumulation and rescue of toxicity using NT4X-167, a novel monoclonal antibody." in: Acta neuropathologica communications, Vol. 1, Issue 1, pp. 56, 2013 (PubMed).

Wittnam, Portelius, Zetterberg, Gustavsson, Schilling, Koch, Demuth, Blennow, Wirths, Bayer: "Pyroglutamate amyloid β (Aβ) aggravates behavioral deficits in transgenic amyloid mouse model for Alzheimer disease." in: The Journal of biological chemistry, Vol. 287, Issue 11, pp. 8154-62, 2012 (PubMed).