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PubChem CID: 9949093
Molecular Formula: C₁₇H₁₁ClN₄O
Cell Premeable: Yes Salt form: No PS-1145 is a potent and selective IκB kinase (IKK) inhibitor (IC₅₀ = 100 nM). Has no effect on PKA, PKC and CKII activity. PS-1145 efficiently inhibits both basal and induced NF-κB activity in PC cells. Enhances TNF-α-induced apoptosis in a multiple myeloma cell line. Smiles: C1=CC(=CN=C1)C(=O)NC2=C3C(=CC(=C2)Cl)C4=C(N3)C=NC=C4 InChi: InChI=1S/C17H11ClN4O/c18-11-6-13-12-3-5-20-9-15(12)21-16(13)14(7-11)22-17(23)10-2-1-4-19-8-10/h1-9,21H,(H,22,23) Inchi Key: JZRMBDHPALEPDM-UHFFFAOYSA-N
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