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PubChem CID: 11234794
Molecular Formula: C₁₃H₂₀Cl₄N₂O
Cell Premeable: Yes Salt form: No PX-478 hydrochloride is an inhibitor of HIF-1α (IC₅₀ of 20-30 μM) with potential antineoplastic activity. PX-478 inhibits HIF-1alpha protein levels and transactivation in a variety of cancer cell lines. The inhibitory effect of PX-478 on HIF-1alpha levels is primarily due to its inhibition of translation because HIF-1alpha translation continues in hypoxia when translation of most proteins is decreased. Smiles: C1=CC(=CC=C1CC(C(=O)O)N)[N+](CCCl)(CCCl)[O-].Cl.Cl InChi: InChI=1S/C13H18Cl2N2O3.2ClH/c14-5-7-17(20,8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19,/h1-4,12H,5-9,16H2,(H,18,19),2*1H/t12-,/m0../s1 Inchi Key: GIGCDIVNDFQKRA-LTCKWSDVSA-N
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