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Purpose
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AZ 3146 is a potent and selective Mps1 (monopolar spindle 1) kinase inhibitor
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Characteristics
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AZ 3146 is a potent and selective Mps1 (monopolar spindle 1) kinase inhibitor (IC₅₀ = 35 nM). Shows selectivity over 46 other kinases including aurora kinase B and Cdk1. AZ 3146 overrides spindle assembly checkpoint and also interferes with chromosome alignment. It has shown to inhibit the recruitment of Mad1, 2 and centromere protein E (CENP-E) to kinetochores.
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Purity
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≥ 98 % by HPLC
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Chemical Name
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9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
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Formula
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C₂₄H₃₂N₆O₃
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Permeability
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Cell-permeable
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Solubility
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DMSO(>10 mg/ml))
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