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Purpose
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SC-202 is an orally bioavailable HDAC inhibitor
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Characteristics
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4SC-202 is an orally available potent HDAC inhibitor (HDACi) specific for class I HDAC isoenzymes with IC50s of 1.2/1.12/0.57 µM for HDAC1/2/3; displays high selectivity over ClassIIa/IIb/III HDACs. Displays antineoplastic activity.
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Purity
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≥ 98 % by HPLC
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Chemical Name
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E)-N-(2-aminophenyl)-3-(1-((4-(1-methyl-1H-pyrazol-4-yl)phenyl)sulfonyl)-1H-pyrrol-3-yl)acrylamide tosylic acid
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Formula
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C₃₀H₂₉N₅O₆S₂
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Permeability
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Cell-permeable
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Solubility
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DMSO(> 50 mg/ml)
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