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Characteristics
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PubChem CID: 9959583
Molecular Formula: C₂₃H₂₇BrFNO₂.C₄H₄O₄
Cell Premeable: Yes Salt form: No Ro 48-8071 is a selective 2,3-Oxidosqualene:lanosterol cyclase (OSC) inhibitor (IC₅₀ = 6.5 nM), blocks cholesterol synthesis in HepG2 cells. Ro 48-8071 exerts strong anti-angiogenic activity by impairing endothelial cell adhesion and migration, and by blocking vessel formation in angiogenesis assays. Smiles: CN(CCCCCCOC1=CC(=C(C=C1)C(=O)C2=CC=C(C=C2)Br)F)CC=C.C(=CC(=O)O)C(=O)O InChi: InChI=1S/C23H27BrFNO2.C4H4O4/c1-3-14-26(2)15-6-4-5-7-16-28-20-12-13-21(22(25)17-20)23(27)18-8-10-19(24)11-9-18,5-3(6)1-2-4(7)8/h3,8-13,17H,1,4-7,14-16H2,2H3,1-2H,(H,5,6)(H,7,8)/b,2-1+ Inchi Key: XCYAYLWZCRGKDS-WLHGVMLRSA-N
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