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  • 产品名称：MCC950(Freebase)

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  • 产品厂商：Biovision
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简单介绍：
MCC950(Freebase)
详情介绍：
Characteristics

PubChem CID: 9910393
Molecular Formula: C₂₀H₂₄N₂O₅S
Cell Premeable: Yes

Salt form: No

MCC950 is a potent and selective NLRP3 inflammasome inhibitor. It blocks the release of IL-1β in macrophages primed with LPS and activated with ATP or nigericin, but it does not inhibit NLRP1, NLRC4, AIM2, TLR2 signaling or priming of NLRP3. Also glutathione S-transferase omega 1 inhibitor. Potential therapeutic agent for NLRP3-associated syndromes, including autoinflammatory and autoimmune diseases.

Smiles: CC(C)(C1=COC(=C1)S(=O)(=O)NC(=O)NC2=C3CCCC3=CC4=C2CCC4)O

InChi: InChI=1S/C20H24N2O5S/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23)

Inchi Key: HUUSXLKCTQDPGL-UHFFFAOYSA-N
Purity ≥ 98 % by HPLC
Chemical Name N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide; CP-456,773; CRID3
Formula C₂₀H₂₄N₂O₅S
Permeability Cell-permeable
Background Synonyms: N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide, CP-456,773, CRID3
Molecular Weight 404.48 g/mol
CAS-No 210826-40-7
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months