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  • 产品名称：Crenolanib

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  • 产品厂商：Biovision
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简单介绍：
Crenolanib
详情介绍：
Characteristics

PubChem CID: 10366136
Molecular Formula: C₂₆H₂₉N₅O₂
Cell Premeable: Yes

Salt form: No

Crenolanib is a highly selective and potent FLT3 tyrosine kinase inhibitor (TKI) with activity against the internal tandem duplication (FLT3/ITD) mutants and the FLT3/D835 point mutants. Also displays inhibitory activity against PDGFRα/β with Kd of 2.1 nM/3.2 nM in CHO cells.

Smiles: CC1(COC1)COC2=CC3=C(C=C2)N(C=N3)C4=NC5=C(C=CC=C5N6CCC(CC6)N)C=C4

InChi: InChI=1S/C26H29N5O2/c1-26(14-32-15-26)16-33-20-6-7-22-21(13-20)28-17-31(22)24-8-5-18-3-2-4-23(25(18)29-24)30-11-9-19(27)10-12-30/h2-8,13,17,19H,9-12,14-16,27H2,1H3

Inchi Key: DYNHJHQFHQTFTP-UHFFFAOYSA-N
Purity ≥ 98 % by HPLC
Chemical Name 1-(2-(5-((3-methyloxetan-3-yl)methoxy)-1H-benzo[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine; CP-868596; ARO 002
Formula C₂₆H₂₉N₅O₂
Permeability Cell-permeable
Background Synonyms: 1-(2-(5-((3-methyloxetan-3-yl)methoxy)-1H-benzo[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine, CP-868596, ARO 002
Molecular Weight 443.54 g/mol
CAS-No 670220-88-9
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months