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  • 产品名称：EXP-3174

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  • 产品厂商：Biovision
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简单介绍：
EXP-3174
详情介绍：
Characteristics

PubChem CID: 108185
Molecular Formula: C₂₂H₂₁ClN₆O₂
Cell Premeable: Yes

Salt form: No

EXP-3174 is a physiologically active metabolite of losartan, produced by cytochrome P450 isoforms in the liver. EXP-3174 is a potent angiotensin II receptor, type 1 (AT1) antagonist (Kis = 0.57 and 0.67 nM for rat and human forms, respectively), producing a depressor response and vasodilatation. When administered intravenously, losartan carboxylic acid is more potent and has a longer duration of action than losartan. However, the metabolite has very low oral bioavailability.

Smiles: CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)C(=O)O)Cl

InChi: InChI=1S/C22H21ClN6O2/c1-2-3-8-18-24-20(23)19(22(30)31)29(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21-25-27-28-26-21/h4-7,9-12H,2-3,8,13H2,1H3,(H,30,31)(H,25,26,27,28)

Inchi Key: ZEUXAIYYDDCIRX-UHFFFAOYSA-N
Purity ≥ 98 % by HPLC
Chemical Name 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carboxylic acid; Losartan carboxylic acid
Formula C₂₂H₂₁ClN₆O₂
Permeability Cell-permeable
Background Synonyms: 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carboxylic acid, Losartan carboxylic acid
Molecular Weight 436.9 g/mol
CAS-No 124750-92-1
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months