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  • 产品名称：RN486

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  • 产品厂商：Biovision
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简单介绍：
RN486
详情介绍：
Characteristics

PubChem CID: 46908026
Molecular Formula: C₃₅H₃₅FN₆O₃
Cell Premeable: Yes

Salt form: No

RN486 is a potent Bruton's tyrosine kinase (Btk) inhibitor (IC₅₀ = 4 nM). When tested with human Ramos B cells or whole blood, RN486 treatment reduces the expression of CD69/B cells proliferation and IgG production by blocking BCR and FcR Signaling

Smiles: CN1CCN(CC1)C2=CN=C(C=C2)NC3=CC(=CN(C3=O)C)C4=C(C(=CC=C4)N5C=CC6=CC(=CC(=C6C5=O)F)C7CC7)CO

InChi: InChI=1S/C35H35FN6O3/c1-39-12-14-41(15-13-39)26-8-9-32(37-19-26)38-30-18-25(20-40(2)34(30)44)27-4-3-5-31(28(27)21-43)42-11-10-23-16-24(22-6-7-22)17-29(36)33(23)35(42)45/h3-5,8-11,16-20,22,43H,6-7,12-15,21H2,1-2H3,(H,37,38)

Inchi Key: ZTUJNJAKTLHBEX-UHFFFAOYSA-N
Purity ≥ 98 % by HPLC
Chemical Name 6-Cyclopropyl-8-fluoro-2-[2-(hydroxymethyl)-3-[1-methyl-5-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino]-6-oxopyridin-3-yl]phenyl]isoquinolin-1-one
Formula C₃₅H₃₅FN₆O₃
Permeability Cell-permeable
Background Synonyms: 6-Cyclopropyl-8-fluoro-2-[2-(hydroxymethyl)-3-[1-methyl-5-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino]-6-oxopyridin-3-yl]phenyl]isoquinolin-1-one
Molecular Weight 606.69 g/mol
CAS-No 1242156-23-5
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months