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  • 产品名称：AT-13148

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  • 产品厂商：Biovision
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AT-13148
详情介绍：
Purpose AT13148 is a potent, ATP-competitive multi-AGC kinase inhibitor that displays antitumor activity.
Characteristics AT13148 blocks AKT, p70S6K, PKA, ROCK, and SGK substrate phosphorylation inducing concentration dependent apoptosis in cancer cells. It also shows anti-tumor efficacy in HER2-positive, PIK3CA-mutant BT474 breast, PTEN-deficient PC3 human prostate cancer and PTEN deficient MES-SA uterine tumor in xenografts. Gene expression studies shows that AT13148 has a predominant effect on apoptosis genes.
Purity ≥ 98 % by HPLC
Chemical Name (S)-1-(4-(1H-pyrazol-4-yl)phenyl)-2-amino-1-(4-chlorophenyl)ethanol
Formula C₁₇H₁₆ClN₃O
Permeability Cell-permeable
Solubility DMSO(>5 mg/ml))
Molecular Weight 313.78 g/mol
CAS-No 1056901-62-2
Restrictions For Research Use only
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months