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Purpose
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A potent estrogen receptor antagonist and Cas9 activator
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Characteristics
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(Z)-4-Hydroxytamoxifen is a metabolite of Tamoxifen (Cat. No. 1551); acts as a potent estrogen receptor antagonist. Displays more potency than the parent compound. Also activates intein-linked inactive Cas9, reducing off-target CRISPR-mediated gene editing.
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Purity
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≥ 98 % by HPLC
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Chemical Name
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4-[(1Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol; 4-OH-TAM
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Formula
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C₂₆H₂₉NO₂
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Permeability
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Cell-permeable
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Solubility
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DMSO (>35 mg/ml) or H2O (>10 mg/ml)
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