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Purpose
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A potent and selective TrkB antagonist
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Characteristics
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ANA-12 is a potent and selective TrkB antagonist that prevents activation of the receptor by BDNF with a high potency. It binds selectively to TrkB and inhibits processes downstream of TrkB without altering TrkA and TrkC functions. In ***** mice model ANA-12 decreases TrkB activity in the brain without affecting neuronal survival. Displays antidepressant properties.
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Purity
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≥ 98 % by HPLC
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Chemical Name
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N-[2-[[(Hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]benzo[b]thiophene-2-carboxamide
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Formula
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C₂₂H₂₁N₃O₃S
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Permeability
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Cell-permeable
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Solubility
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DMSO (>20 mg/ml)
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